Our Approach
We combine AI-supported protein design, structural biology, functional genomics and translational oncology to develop a new generation of precision therapeutics against pancreatic cancer. Starting from clinically relevant targets, we design large libraries of small protein binders and use experimental screening to identify the most promising candidates. Patient-derived organoids and innovative 3D models then allow us to validate and optimize these molecules in disease-relevant systems. Click on the steps below to learn more about the technologies behind them.
Team
The PrepAIred consortium brings together expertise in computational protein design, structural biology, oncology, functional genetics, surgery, and translational medicine. Interdisciplinarity is a key asset of the consortium, enabling close collaboration between computational scientists, basic researchers, and clinicians. By integrating AI-driven protein engineering with deep clinical and biological insight, we aim to accelerate the development and translation of next-generation biologics against pancreatic cancer from computational design to patient-relevant applications.
Gregor HageluekenStructural Biology Michael HölzelExperimental Oncology Jonathan Schmid-BurgkFunctional Immunogenomics Alexander SemaanOncological Surgery Marieta TomaExperimental Pathology Tobias BaldTumor Immunology
Photograph: Felix Heyder, University Clinics Bonn
Funding & Support
PrepAIred is part of the German Pancreatic Cancer Alliance and grateful for support by the German Cancer Aid.
Supported by Deutsche Krebshilfe, Charité, University Clinics Bonn, and the University of Bonn.